College football odds, picks, predictions for Week 2, 2024: Proven computer backs Oklahoma in best bets (2024)

The betting market was way off on some teams in Week 1, with Clemson and being two of the teams that were overvalued in the college football odds. The Tigers will be looking to bounce back as heavy favorites when they host Appalachian State on Saturday during the Week 2 college football schedule. Clemson opened as a 16-point favorite in the Week 2 college football odds, but that Week 2 college football spread is already up to -18. The Tigers finished with just 188 yards of offense in their 34-3 loss to No. 1 Georgia last week, so how should you approach them with your Week 2 college football bets?

There are two ranked vs. ranked matchups on Saturday in Week 2, with No. 10 Michigan vs. No. 4 Texas (-7) at noon ET and No. 14 Tennessee (-8) vs. No. 24 NC State at 7:30 p.m. ET. Other intriguing games in Week 2 include No. 17 Kansas State (-10) at Tulane, No. 21 Iowa (-3) vs. Iowa State and No. 19 Kansas (-5.5) at Illinois. Before locking in any Week 2 college football picks, be sure to see the latest college football predictions from SportsLine's proven model.

The model simulates every FBS college football game 10,000 times. Since its inception, it has generated a profit of over $2,000 for $100 players on its top-rated college football picks against the spread. It is also coming off a profitable 13-9 season on top-rated spread picks. Anyone who has followed it has seen strong returns.

Now, it has turned its attention to the latest college football oddsand Week 2college football betting lines on the spread, money line, and over/under.Head here to see every pick.

Top college football predictions for Week 2

One of the college football picks the model is high on during Week 2: South Carolina (+10) covers against Kentucky at 3:30 p.m. ET on Saturday. The Wildcats got off to a strong start with a 31-0 win over Southern Miss in Week 1, but they barely played five minutes of the second half before the game was called off due to weather. They are facing a much tougher opponent this week, and that lack of game action could hurt them against a South Carolina team that rallied for a win over Old Dominion.

Gameco*cks freshman quarterback LaNorris Sellers could wind up being one of the most electric quarterbacks in the conference this season, bringing a unique dual-threat ability to the table. He rushed for 68 yards and the game-winning touchdown last week, and he will create problems for Kentucky's defense on Saturday afternoon. SportsLine's model anticipates a low-scoring game between these schools, with South Carolina covering as double-digit underdogs in over 60% of simulations.See the rest of its Week 2 college football picks here.

Another prediction: No. 15 Oklahoma (-29) easily covers the huge spread against Houston in a 7:45 p.m. ET kickoff on Saturday. The Cougars struggled during their first season in the Big 12, going 2-7 within the conference and 4-8 overall. They were unable to put that rough campaign behind them last week, getting blown out by UNLV in a game where they closed as 3.5-point home favorites.

This is not going to be an easy spot to bounce back from that performance, as Oklahoma is one of the best teams in the conference and is coming off a 51-3 win over Temple. The Sooners debuted Purdue transfer wide receiver Deion Burks, who caught three touchdown passes on six receptions. Oklahoma has covered the spread in five straight games in September, and the model has the Sooners covering in 60% of the latest simulations.See picks for every other game in Week 2 here.

How to make college football picks for Week 2

The model has also made the call on who wins and covers in every FBS matchup in Week 2, and it's calling for multiple underdogs to win outright.You can only get every pick for every game at SportsLine.

So what college football picks can you make with confidence, and which underdogs win outright? Check out the latest college football odds below, then visit SportsLine to see which teams win and cover the spread, all from a proven computer model that has returned over $2,000 in profit since its inception, and find out.

College football odds for Week 2

See full Week 2 college football picks, odds, predictions here

Friday, Sept. 6

BYU at SMU (-11.5, 56)

Duke at Northwestern (-2.5, 37)

Saturday, Sept. 7

Texas at Michigan (+7.5, 42.5)

Arkansas at Oklahoma State (-7.5, 62.5)

Kansas State at Tulane (+10, 48.5)

South Carolina at Kentucky (-10, 42.5)

Iowa State at Iowa (-3, 35)

BayloratUtah(-14.5, 54.5)

Michigan State at Maryland (-9.5, 44)

Virginia at Wake Forest (-2, 57)

South Florida at Alabama (-31, 63.5)

Western Michigan at Ohio State (-38, 54)

Colorado at Nebraska (-7.5, 59)

Houston at Oklahoma (-29, 49)

Tennessee vs. NC State (+8, 61)

Boise State at Oregon (-19.5, 61.5)

Mississippi State at Arizona State (-6.5, 59.5)

Utah State at USC (-28.5, 63.5)

College football odds, picks, predictions for Week 2, 2024: Proven computer backs Oklahoma in best bets (2024)

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